Diagnostic potential of markers detected in 7-day culture supernatants for TB disease.

Median levels (and ranges in parenthesis) of analytes detected in 7-day whole blood culture supernatants and accuracy in the diagnosis of TB disease are shown. P-values were calculated using the Mann Whitney U test. Only analytes with AUC≥70% are shown. Cut-off values, sensitivity and specificity were selected based on the Youden’s index. AUC = Area under the receiver operator characteristics curve. 95% CI = 95% confidence interval. All analyte levels are in pg/ml except for SAA (ng/ml). The levels shown for the the different antigens were corrected for background by subtraction of the unstimulated levels.