Maternal factor Trim75 contributes to Zygotic Genome Activation program in mouse early embryos

Zygotic genome activation (ZGA) marks the first transcription event in life, and human embryo developmental arrest has been highly correlated with ZGA failure in clinical studies. We utilized published single-cell RNA sequencing data and RNA-seq data to identify Trim75 is a potential driver of minor ZGA and may recruit EP300 and establish H3K27ac in the gene body of minor ZGA genes. Overall design: Single-cell RNA sequencing data of induced 2-cell-like transition state and RNA-Seq data of Trim75 overexpression data analysis.