Fyn-mediated phosphorylation of Grin2b

In rat brain and spinal cord, kinase activity of Fyn is needed for tyrosine phosphorylation of the Grin2b (NR2B) subunit of the NMDA receptor complex in response to Bdnf-mediated activation of the Ntrk2(TrkB) receptor (Mizuno et al. 2003, Li et al. 2017). The exact stoichiometry of this reaction and involvement of other proteins is not known.

在鼠脑和脊髓中，Fyn 酪氨酸激酶的活性对于NMDA受体复合体Grin2b（NR2B）亚单位的酪氨酸磷酸化至关重要，该磷酸化过程响应于Bdnf介导的Ntrk2（TrkB）受体激活（Mizuno等人，2003年，Li等人，2017年）。此反应的精确化学计量比以及其他蛋白的参与情况尚未明确。