NHLBI TOPMed: Study of African Americans, Asthma, Genes and Environment (SAGE)

This is a parallel case-control pharmacogenetic study of bronchodilator drug response among African American children with and without asthma. Each participant had spirometry measured using the KoKo PFT System. Asthmatic participants were administered with 4 puffs of HFA Albuterol. Healthy participants were given a baseline spirometry test. The overall goal is to identify genetic factors which are predictive of drug response in children with asthma. The principal tools include a questionnaire and biological specimen collection. Participants were 8-21 years old at time of recruitment. Children with asthma have physician-diagnosed asthma, symptoms and medications.]]>
TOPMed Whole Genome Sequencing Methods: Freeze 9README concerning Subject identifiers for freeze9 SAGE phs000921TOPMed Whole Genome Sequencing Methods: Freeze 10Eligibility Subjects meeting the following criteria will be eligible for participation: Ages between 8 and 21 years old Parents and Grandparents of the same ethnicity [self-identified] History of asthma [physician diagnosed or currently taking asthma medication] Having experienced symptoms of coughing, wheezing or shortness of breath in the past 2 years No respiratory infections for ≥ 6 weeks No asthma exacerbations for ≥ 6 weeks ≤ 10 pack year smoking history, no smoking in the last year If pregnant, < 3rd trimester No other history of lung diseases ]]>
Time Line February 2006 - First qualifying participant December 2014 - Whole Genome Sequencing ]]>