Study on the molecular mechanism of relapse and drug resistance in T lymphoblastic lymphoma/leukemia

Increasing evidence shows that non-coding RNA in peripheral blood is closely related to drug resistance and relapse of T lymphoblastoma/leukemia. The main focus of this study is to observe the relationship between circular RNA(circRNA) and drug resistance and relapse status of lymphoblastoma/leukemia. Overall design: The samples were divided into two groups according to drug sensitivity and drug resistance, and circDNA sequencing was performed on the peripheral blood samples of the two groups.CircRNAs were predicted by CIRI software and calculated the expression by junction reads at back-splicing sites then normalized by SRPBM. Differentially expressed genes between groups were predicted using edgeR software. |log2 FC| >1 and P value < 0.05 were considered thresholds for differentially expressed circRNAs