Identification of candidate genes associated with statin.
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HepG2 (n = 4), Hep3B (n = 3) and 480 LCLs derived from participants of the Cholesterol and Pharmacogenetics (CAP) clinical trial were exposed to either 2 µM activated simvastatin or sham buffer for 24 hours, and gene expression was quantified on the Illumina HTref8v3 bead chip. Genes expressed in both LCLs and normal human liver (n = 60, GEO dataset GSE28893) were identified and tested for evidence of statin-induced changes in gene expression.
创建时间：
2012-11-15
