Signaling cascades and metabolic pathways enriched at the BBB and peripheral endothelial cells.

A–B) BBB enriched pathways. Ingenuity Pathway Analysis (IPA) software was utilized to identify signaling cascades (A) and metabolic pathways (B) that are significantly enriched at the BBB. For this analysis BBB enriched transcripts identified in Table S6 were utilized. Pathways in which p-value <0.05 are displayed.
C–D) Peripheral vascular enriched pathways. IPA software was utilized to identify signaling cascades (C) and metabolic pathways (D) that are significantly enriched in peripheral vessels compared to brain vessels. For this analysis peripheral enriched transcripts identified in Table S7 were utilized. Pathways in which p-value <0.05 are displayed.