Copper-Catalyzed Three-Component Cyano­trifluoro­methyla­tion/Azido­trifluoro­methyla­tion and Carbo­cycli­zation of 1,6-Enynes

A novel three-component
strategy for the cyano­trifluoro­methyla­tion/azido­trifluoro­methyla­tion
and carbocyclization of 1,6-enynes is developed. The reaction proceeds
smoothly under a moderate temperature by using a copper catalyst,
which provides a rapid and concise access to addition–carbocyclization
products. Furthermore, the products obtained can be useful building
blocks in discoveries of lead compounds and other biologically active
CF3-containing heterocycles.