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Dynamic ventilation functional MRI of the lung with sub-millimeter spatial resolution and millisecond temporal resolution

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中国科学院兰州化学物理研究所科学数据中心2026-01-12 更新2026-01-17 收录
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Pulmonary dynamic ventilation dysfunction is a common feature of various lung diseases, including chronic obstructive pulmonary disease (COPD) [1], cystic fibrosis [2], and asthma [3]. Regional assessment of ventilation dynamics offers substantial potential to enhance diagnostic accuracy and therapeutic monitoring in these conditions. Although current clinical evaluations primarily depend on global pulmonary function tests, emerging imaging modalities such as fourdimensional computed tomography (4D-CT) [4] and phase-resolved functional lung (PREFUL) imaging [5] enable temporal observation of structural and ventilation changes. However, these techniques are fundamentally limited in their ability to visualize time-of-flight (TOF) gas flow patterns within airways and alveolar spaces-critical parameters for the direct assessment of regional gas diffusion efficiency.
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中国科学院兰州化学物理研究所科学数据中心
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2026-01-12
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