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Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs

ChEBI2014-05-21 更新2026-07-21 收录

罕见病机制

疾病建模

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-57828 数据链接链接失效反馈

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资源简介：

Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs

应用场景：

创建时间：

2014-05-21

ICF综合征表观遗传学

疾病建模

DNA methyltransferase 3B (DNMT3B) is the major DNMT that methylates mammalian genomes during early development. Mutations in human DNMT3B disrupt genome-wide DNA methylation patterns and result in ICF

NIAID Data Ecosystem100

Different cases for patient PAT00001 and the elements of the vertex alphabet.

医疗网络分析

疾病建模

Different cases for patient PAT00001 and the elements of the vertex alphabet.

NIAID Data Ecosystem60

A study of gene expression, structure, and contractility of iPSC-Derived Cardiac Myocytes from a family with heart disease due to LMNA mutation

器官疾病机制研究

疾病建模

Genetic mutations to the Lamin A/C gene (LMNA) can cause heart disease, but the mechanisms making cardiac tissues uniquely vulnerable to the mutations remain largely unknown. Further, patients with LM

NIAID Data Ecosystem40

Reliability of 3D Cortical Spheroids Generation from Human Pluripotent Stem Cells. Reliability of 3D Cortical Spheroids Generation from Human Pluripotent Stem Cells

干细胞研究

疾病建模

Here we assess the reliability of human cortical spheroid differentiation cultured in xeno-free, feeder-free conditions. We find high reliability in differentiation across multiple hiPSC lines as well

NIAID Data Ecosystem60

Additional file 11 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

单细胞转录组学

疾病建模

Additional file 11: SuppTable4. Differential expression analysis between hiPSC-N and hiPSC-A.

DataCite Commons2024-08-18 更新50