Expression profiling across mouse epithelial tissues

To characterize genes, pathways, and transcriptional regulators enriched in the mouse cornea, we compared the expression profiles of whole mouse cornea, bladder, esophagus, lung, proximal small intestine, skin, stomach, and trachea. Total RNA was purified from esophagus, lung, proximal small intestine, skin, stomach, and trachea. Data from previous studies in the lab (cornea, GSE43155; bladder, GSE15770; and E18.5 skin, GSE15772) were utilized in the comparison.为解析富集于小鼠角膜的基因、信号通路及转录调控因子，本研究对完整小鼠角膜、膀胱、食管、肺、近端小肠、皮肤、胃及气管的表达谱进行了比较分析。本研究从食管、肺、近端小肠、皮肤、胃及气管中纯化得到总RNA；本次比较同时纳入了本实验室既往研究产生的相关数据（角膜：GSE43155；膀胱：GSE15770；E18.5皮肤：GSE15772）。