Pattern of kB1-kB1 interaction.

(A) The intermolecular loop-to-loop interaction energies of the tetramer in water (blue bar) and in its membrane-bound state (orange bar) are shown. The interaction energies were averaged across 22.3–5.0 µs. The error bar represents the standard deviation of the average values. Matrices representing the contact frequencies for the tetramer in (B) water and (C) in its membrane-bound state are shown. The contact frequency for each AA residue pair of the tetramer in water and in its membrane-bound state were measured from 0–2.6 and 22.4–5.0 µs, respectively.