Figure 5

<b>Figure 5 | Activation of hM3Dq signaling in astrocytes does not alter baseline behavior. a</b>, Experimental approach and timeline of clozapine-N-oxide (CNO) treatment and behavioral assessments. All mice received CNO (1mg/kg i.p.) 30 minutes before each behavioral task. <b>b</b>, Total distance traveled of an open field (n=7 male astro-hM3Dq, 11 female astro-hM3Dq, 13 male control, and 14 female control). <b>c</b>,<b> </b>Time spent in the centre of the locomotor apparatus (n=7 male astro-hM3Dq, 11 female astro-hM3Dq, 13 male control, and 14 female control). <b>d</b>,<b> </b>Time spent on the light side of a light/dark box (n=7 male astro-hM3Dq, 11 female astro-hM3Dq, 13 male control, and 14 female control). <b>e</b>, Time spent in the open arm of an elevated plus maze (n=7 male astro-hM3Dq, 11 female astro-hM3Dq, 13 male control, and 14 female control). <b>f</b>, Percentage of spontaneous alternations in Y maze (n=7 male astro-hM3Dq, 11 female astro-hM3Dq, 13 male control, and 14 female control). <b>g</b>, Time spent interacting with a juvenile mouse in a three-chamber social preference task (sociability) (n=7 male astro-hM3Dq, 11 female astro-hM3Dq, 13 male control, and 12 female control). <b>h</b>,<b> </b>Time spent interacting with a novel juvenile mouse in a three-chamber social novelty task (social recognition) (n=7 male astro-hM3Dq, 11 female astro-hM3Dq, 13 male control, and 12 female control). Each symbol on the graph represents an individual animal (blue=males, pink=females). Data are presented as meanSEM. Unpaired, two-tailed Student t-test. ns&gt;0.05.