File S1 - Functional Magnetic Resonance Imaging Connectivity Analyses Reveal Efference-Copy to Primary Somatosensory Area, BA2

Contains the following: Table S1: Clusters of activity resulting from the contrasts PASS>ACT and EMGpm<0. Figure S1: Illustration of the BA2 region used in PPI analysis for all the 14 subjects. The green shows the 6 mm sphere centered in the peak. The red shows the anatomical region of BA2. And yellow are the overlaps as well as the region used in the PPI analysis. Figure S2: Illustration of the Partial Correlation Logic. (A) If a ROI has an actual BOLD response similar during ACT and PASS blocks, regressing out the time course of the generic task (after HRF convolution) leaves only noise in the residuals. (B) If a ROI responds differently to ACT and PASS, regressing out the same generic task retains the variance between conditions in the residual time-course. These residuals can then serve to track how differences between ACT and PASS are transmitted from ROI to ROI. The time-courses in this figure are not actual data, but simulated data to caricature the concept. Figure S3: Graphical illustration of the six models compared in DCM. The RFX Bayesian model comparison results is in the graph on the right. The numbers in the top left of each graph correspond to those in the x-axis of the chart. Figure S4: Graphical illustration of the models including M1 and PM compared in the DCM analysis. The RFX Bayesian model comparison results is in the graph on the bottom. The numbers in the right underside of each graph correspond to those in the x-axis of the chart. Note that the generic task is always included as modulator of both BA3b and BA2, as in the previous analysis. Figure S5: PPIs group results. Green color: second level PPI results currently presented in the manuscript (T<4.02 at punc<0.001, all survive qfdr<0.05). The eigen-vectors were extracted from a 6 mm sphere centered on the local maxima within the anatomical BA2 ROI. Eigen-vectors were extracted at the single subject level at punc<0.001 for 14 out of 17 subjects. Red color: second level PPI results for the entire group of 17 subjects (T>3.69, punc<0.001, all voxels also survive qfdr<0.05). As for green, the eigen-vectors were extracted from a 6 mm sphere centered on the local maxima within the anatomical BA2 ROI. Eigen-vectors were extracted at single subject level within that region from all voxels where a subject showed a correlation with EMG, at punc<0.001 threshold for 14 out of 17 subjects, and at punc<0.5 for the remaining 4. Yellow color: overlap between Red and Green. Figure S6: PPIs group results. Green color: second level PPI results currently presented in the manuscript (T<4.02 at punc<0.001, all survive qfdr<0.05). The eigen-vectors were extracted from a 6 mm sphere centered on the local maxima within the anatomical BA2 ROI. Eigen-vectors were extracted at the single subject level at punc<0.001 for 14 out of 17 subjects. Red color: second level PPI results for the entire group of 17 subjects (T>3.69, punc<0.001, all voxels also survive qfdr<0.05) using the method define above (supplementary method S4 in File S1). Yellow color: overlap between Red and Green. Supplementary Method S1: Dynamic causal modeling (DCM). Supplementary Method S2: Influence of the EEG artifact on the partial correlation analyses. Supplementary Method S3: PPI analysis including all 17 subjects. Supplementary Method S4: PPI results using group-level results to define ROIs.
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