Total Synthesis of the Dimeric Phytocannabinoid Cannabitwinol (CBD Dimer) and Its Analogues

A new synthetic route to access the natural product phytocannabinoid
cannabitwinol (1) starting from commercially available
raw materials is disclosed. We have also demonstrated the synthesis
of other related dimers, including their enantiomers, using the present
sequence. This route avoids the legal constraints concerning the acquisition
of cannabis plant material or CBD.