H3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples

ChEBI2015-12-14 更新2026-07-12 收录

神经退行性疾病表观遗传

脑组织组蛋白修饰分析

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H3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples

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2015-12-14

肌萎缩侧索硬化的DNA甲基化特征

神经退行性疾病表观遗传

甲基化生物标志物发现

目的：本研究旨在通过比较散发性肌萎缩侧索硬化（amyotrophic lateral sclerosis，ALS）患者和健康对照（health control,HC）全血样本的DNA甲基化特征，探索DNA 甲基化在 ALS发病中的作用。方法：共纳入 2020年12月至2021年5月期间在我院神经科门诊就诊的临床确诊、临床拟诊、实验室支持-临床拟诊的散发性 ALS 患者32例作病例组，选择同时期

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神经退行性疾病表观遗传

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Genome wide Methylation profiling of DNA extracted from post-mortem forebrains of PSP patients (n=94) and of controls (n=72). The Illumina Infinium HumanMethylation450 BeadChip was used representing 4

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The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review

神经退行性疾病表观遗传

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ImportanceEpigenetic modifications of the genome, such as DNA methylation and histone modifications, have been reported to play a role in neurodegenerative diseases (ND) such as Alzheimer’s disease (A

Figshare2016-12-15 更新40

H3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples. Homo sapiens

神经退行性疾病表观遗传

染色质修饰分析

Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder resulting from expansion in the number of CAG repeats in the coding region of exon 1 of the Huntingtin (HTT) gene. One of

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Differential 5-methylcytosine and 5-hydroxymethylcytosine in Parkinson’s and Alzheimer’s Disease.. Differential 5-methylcytosine and 5-hydroxymethylcytosine in Parkinson’s and Alzheimer’s Disease.

神经退行性疾病表观遗传

DNA甲基化与羟甲基化分析

Background: 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC), are distinct epigenetic marks that help regulate gene expression in the mammalian brain. Existing studies ha

NIAID Data Ecosystem40

H3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples

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