All TCR structures used for the analysis.

a) Species: h = homo sapiens, m = mus musculus. b) Bound state: u = unbound, 1 = MHCI, 2 = MHCII, s = superantigen. More detailed information is available in S1 Table. c) Structure 2xn9 and 2icw are not considered as MHC II bound TCRs, since the TCRs only contact the super-antigens. d) WT with solubility mutations acc. to ref. [63]. More detailed information is available in S2 Table. All TCR structures used for the analysis.