Characterization of NR2F2 Orphan Nuclear Receptor in Estrogen Receptor alpha mediated Transcriptional Regulation in Breast Cancer Cells

NR2F2 is a member of the steroid/thyroid hormone receptor superfamily and plays a crucial role in organogenesis, angiogenesis, cardiovascular development and tumorigenesis. However, there is limited knowledge about gene regulation by NR2F2 in breast cancer. To understand the molecular mechanism of NR2F2 in breast cancer, we determined the cistrome and transcriptome of NR2F2 in the ER positive breast cancer cell lines (MCF7 and T47D) using the ChIP-seq and RNA-seq methods. This work provides evidences that NR2F2 is associated with ER-mediated transcriptional programs.