Data from: Cyanobacteria maintain constant protein concentration despite genome copy-number variation

The cyanobacterium Synechococcus elongatus PCC 7942 has multiple copies of
its single chromosome, and the copy number varies in individual cells,
providing an ideal system to study the effect of genome copy-number
variation on cell size and gene expression. Using single-cell fluorescence
imaging, we found that protein concentration remained constant across
individual cells regardless of genome copy number. Cell volume and the
total protein amount from a single gene were both positively, linearly
correlated with genome copy number, suggesting that changes in cell volume
play an important role in buffering genome copy-number variance. This
study provides a quantitative examination of gene expression regulation in
cells with variable genome copies and sheds light on the compensation
mechanisms for variance in genome copy number.