Differential expression of circular RNA in oral leukoplakia: novel potential biomarkers exploration for diagnosis and prognosis of precancer

6 pairs of OLK tissues and normal oral mucusal (NOM) tissues were obtained to detect circRNAs expression.The profile data showed that 366 circRNAs were significantly dysregulated in the OLK tissues, including 65 upregulated and 301 downregulated circRNA transcripts.There are 28 circRNAs were discovered firstly. 7 out of 10 selected circRNAs were further validated using Qrt-PCR Overall design: Examination of different circular RNA expression in 2 tissue types. Control samples are identical to healthy oral mucosa samples in GSE131182.