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Engineered APOBEC3A deaminase variants for highly accurate and efficient cytosine base editing

NIAID Data Ecosystem2026-03-14 收录

胞嘧啶碱基编辑

基因编辑脱靶评估

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA938578 数据链接链接失效反馈

官方服务：

资源简介：

RNA off-target assessment of CBE variants.

应用场景：

创建时间：

2023-02-24

碱基编辑技术

基因编辑脱靶评估

The SNAP-ADAR tool enables precise and efficient A-to-I RNA editing in a guideRNA-dependent manner by applying the self-labeling SNAP-tag enzyme to generate RNA-guided editases in cell culture. Here

NIAID Data Ecosystem150

Engineered APOBEC3A deaminase variants for highly accurate and efficient cytosine base editing

基因编辑

胞嘧啶碱基编辑

Developing highly accurate and efficient cytosine base editors through structure-guided molecular evolution of APOBEC3A deaminase.

NIAID Data Ecosystem110

Engineered APOBEC3A deaminase variants for highly accurate and efficient cytosine base editing

胞嘧啶碱基编辑

基因治疗优化

Evaluation of Cas9-dependent off-target activity and the potential for correction of pathogenic SNVs.

NIAID Data Ecosystem90

Whole genome analysis for 163 guide RNAs in Cas9 edited mice reveals minimal off-target activity

基因编辑脱靶评估

大鼠基因组测序

In order to assess the risk of off-target mutagenesis associated with Cas9 mutagenesis, whole genome sequencing was applied to compare the genomes of 50 Cas9-derived founder mice to 28 untreated inbre

NIAID Data Ecosystem120

Td-BE-NGS-3

基因编辑脱靶评估

碱基编辑器安全性

Cas9-dependent and Cas9-independent off-target assessments of Td-BEs

NIAID Data Ecosystem90