Reactivity-Based RNA Profiling (RBRP) determined transcriptome interactions of small molecule drugs
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https://www.ncbi.nlm.nih.gov/sra/SRP431834
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资源简介：
We developed Reactivity-Based RNA Profiling (RBRP) approach to determine the off-target transcriptome interactions of small molecule drugs. Deep sequencing was used to locate and quantify drug-promoted acylation of RNA 2´-hydroxyl groups as a proxy of RNA-drug interaction in HEK293. Overall design: The sequencing experiments were performed in two biological replicates. Comparative analysis of deep sequencing data using a customized pipeline identifies drug binding events.
创建时间：
2023-12-07
