Novel propolis-aloe vera nanofilms as drug delivery systems for acute wound healing

Objective: To investigate the effect of nanopore rapid film (NRF) co-loaded with propolis and aloe vera extract in the treatment of wound healing. Methods: The porosity, mechanical properties, and water vapor transmittance rate (WVTR) of the materials were determined, and the effect of P-A-NRF in promoting cell proliferation and migration was evaluated, and the mechanism of wound healing in a mouse full-thickness wound model was provided. Results: P-A-NRF is rapidly film-forming within 5 min, which has a waterproof effect. The cell viability rate of P-A-NRF was more than 80%, and the cell migration rate reached more than 50%. In vivo experiments, the P-A-NRF group achieved a 98% healing rate at 14 days 70% in the commercially available liquid band-aid group, with faster wound healing. Conclusion: The film formed by P-A-NRF is uniform, soft, and malleable. It can enhance cell viability, promote cell proliferation and migration, and accelerate wound healing mainly by reducing inflammation, and antibacterial, and promoting angiogenesis and collagen deposition, which is a promising wound dressing.