Role of circulating microRNAs in patients with dengue infection

miRNAs are found to be extremely stable in extracellular fluids of mammals, such as blood plasma, serum, etc. The expression profiles of these circulating miRNAs have immense potential for use as novel minimally invasive markers in monitoring Dengue diseases progression. Here Using high-throughput small RNA sequencing methods followed by in silico analysis, the levels of circulating miRNAs analysed between patients with uncomplicated dengue infection (DI, n=9), Dengue with a warning sign (DWS, n=14), and severe dengue (DS, n=16). We also used plasma from nine dengue patients followed–up at two-time points (Day ’0’ and Day ’5”) for small RNA sequencing. The total_miRNA_count_low2up.txt (containing normalized miRNAs counts) is a follow-up study, comparing Dengue severe samples with 5 days followup. The total_miRNA_count_up2low.txt (containing normalized miRNAs counts) is a follow-up study two, comparing Dengue infection samples with 5 days followup.