Transcriptomic analysis reveals the dynamic changes of immune responses during the development of creeping fat in Crohn's disease

In Crohn's disease, creeping fat is the characteristic expansion of mesenteric adipose tissue wrapping around the inflamed intestine. Through a comparative transcriptomic analysis of creeping fat and normal-looking mesenteric adipose tissues from patients with Crohn's disease and non-Crohn's disease, we found that a dynamic transcriptional and cell compositional change occurs during the progression from non-Crohn's disease to Crohn's disease, and finally to creeping fat. Comparative gene expression profiling analysis of RNA-seq data for patients with CD CF, CD MAT and Con MAT. **Submitter declares that the raw data cannot be deposited due to hospital policy**