Total Synthesis of Thaxtomin A and Its Stereoisomers and Findings of Their Biological Activities
收藏NIAID Data Ecosystem2026-03-07 收录
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The first and facile total synthesis of thaxtomin A and its three stereoisomers has been achieved. The synthetic approach involves intramolecular nucleophilic cyclization of an amide toward a ketoamide group to produce a C-hydroxydiketopiperazine scaffold. The most amazing discovery was that each of the four stereoisomers of TA exhibits different phytotoxic, fungicidal, and antiviral activities.
创建时间：
2016-02-18
