BET Protein Inhibition shows Efficacy Against JAK2V617F-Driven Neoplasms

ChEBI2013-08-20 更新2026-07-21 收录

实体瘤靶向治疗

表观遗传药物研发

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-1817 数据链接链接失效反馈

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BET Protein Inhibition shows Efficacy Against JAK2V617F-Driven Neoplasms

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2013-08-20

Selective Inhibition of the Second Bromodomain of BET Family Maintains Anti-Tumor Efficacy and Improves Tolerability. Selective Inhibition of the Second Bromodomain of BET Family Maintains Anti-Tumor Efficacy and Improves Tolerability

表观遗传药物研发

肿瘤靶向治疗

Here we report the discovery of ABBV-744, a first in class, highly potent and selective inhibitor of BET family BD2 domains with drug like properties. ChIP-seq analysis revealed that ABBV-744 displace

NIAID Data Ecosystem70

BindingDB Entry 50018665: Targeting mutated GTPase KRAS in tumor therapies.

药物靶点预测

实体瘤靶向治疗

Small molecule binding data for protein GTPase HRas and GTPase KRas, Uniprot P01112 and P01116

DataCite Commons2024-04-26 更新50

Phase 1, Two-Part, Multicenter, Non-randomized, Open-label, Multiple Dose First-In-Human Study of DS-8201A, in Subjects With Advanced Solid Malignant Tumors

实体瘤靶向治疗

药物临床试验

This is an open-label, two-part, multiple study to evaluate the safety and tolerability of DS-8201a in patients with advanced solid malignant tumors.

DataCite Commons2025-06-04 更新10

Study of XL281 in Adults With Solid Tumors

实体瘤靶向治疗

临床试验剂量探索

The purpose of this study is to determine the safest dose of the multiple Raf kinase inhibitor (including c-Raf, B-Raf, and the activated mutant B-RafV600E) XL281, how often it should be taken, and ho

NIAID Data Ecosystem70

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates

HDAC7抑制剂设计

表观遗传药物研发

The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new

NIAID Data Ecosystem30

BET Protein Inhibition shows Efficacy Against JAK2V617F-Driven Neoplasms

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