In vivo and in vitro IC50s and resistance factors overview.

Upper panel: In vivo and in vitro IC50 values obtained for the WT (IPO323) ±S.E. (triplicate). Lower panel: resistance factors (RFs) based on IC50 assessment for a selected subset of representative strains. Presented values are based on the ratio of the means of three individual determinations for the in vivo values and based on the ratio of a single determination for the in vitro values. Presented in vitro values were obtained by calibrating mitochondrial dilutions to obtain similar initial velocity (see material and methods). Cbx strains were originally obtained on Carboxin selection media, Flu on Fluopyram, Bos on Boscalid, Izm on Isopyrazam, Ol on pyrrole compound A. nd*: IC50 could not be determined because fitted curves were not tending to 100% inhibition at infinite AI concentration. FR** (full resistance), no sufficient inhibition detected at highest inhibitor concentration tested.