Pd(II)-Catalyzed Synthesis of Furo[2,3‑b]pyridines from β‑Ketodinitriles and Alkynes via Cyclization and N–H/C Annulation

A Pd­(II)-catalyzed synthesis of furopyridines has been developed from β-ketodinitriles and alkynes via an unusual N–H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan and pyridine rings through the formation of C–C, CC, C–O, C–N, and CN bonds are the important features. The synthetic applicability is further demonstrated through a series of postsynthetic alterations.