Unraveling the molecular mechanism of hyperlipidemia using integrated lncRNA and mRNA microarray data

Long non-coding RNAs (lncRNAs) play key roles in various diseases; however, their functions in hyperlipidemia (HLP) are unclear. In the present study, microarray technology was utilized to analyze the differential expression of lncRNAs and mRNAs in liver tissues of HLP ApoE-/- mice and control mice. We identified 104 and 96 differentially expressed lncRNAs and mRNAs, respectively. Differentially expressed genes were significantly enriched in biological processes such as nitric oxide biosynthesis, innate immune response, and inflammatory response. Two pairs of target genes and 38 transcription factors with regulatory functions in HLP were predicted based on the lncRNA and mRNA co-expression network. The lncRNA expression profile changes significantly in liver tissues of HLP mice model, and can provide new targets for research and treatment. A total of 10 samples were analyzed,including 5 control samples and 5 model samples.