Porcine ZC3H11A is essential for the proliferation of pseudorabies virus (PRV) and porcine circovirus 2 (PCV2) by mediating mRNA export

Purpose:ZC3H11A has been reported to play a role in RNA transport. The purpose of this study was to detect the differentially expressed genes after ZC3H11A knockout. Methods: RNA sequencing was performed on PK-15 cell line (WT) and ZC3H11A-/- using Illumina platform, and three repeated RNA sequencing results were obtained. Results: Using an optimized data analysis workflow,different expression genes were obtained and RNA transport pathway was enriched through KEGG pathway analysis. Conclusions: In this study, we observed that ZC3H11A interacted with TRanscription and the EXport complex (TREX) and played an important role in mRNA export. PK-15 cell line (WT) and ZC3H11A-/- cells