Lymphopenia-induced T cell exhaustion in STING gain-of-function mouse model

ChEBI2024-01-07 更新2026-07-12 收录

免疫学模型研究

T细胞耗竭

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-13658 数据链接链接失效反馈

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Lymphopenia-induced T cell exhaustion in STING gain-of-function mouse model

创建时间：

2024-01-07

Association between HPK1 expression and T-cell exhaustion. Association between HPK1 expression and T-cell exhaustion

肿瘤免疫学

T细胞耗竭

We aimed to investigate the association between HPK1 expression and exhausted status of tumor. Overall design: Bulk RNA-seq was performed on fresh-frozen tissue samples of renal cell carcinoma.

NIAID Data Ecosystem60

RNA-Seq analysis of P14 CD8+T cells in B16-GP tumors

肿瘤浸润T细胞

T细胞耗竭

CD8+ T cells play an important role in fighting against tumors. However, CD8+ T cells often become functionally impaired or “exhausted” in the tumor microenvironment. T cell exhaustion is a major hurd

NIAID Data Ecosystem60

Correlations of clinical parameters and T cell markers.

病毒感染免疫反应

T细胞耗竭

Spearman correlations of HCV-RNA and ALT with expression of activation and exhaustion markers and median expression of these markers in patients with F0–F2 versus F3–F4 fibrosis in all HCV-monoinfecte

Figshare2015-12-02 更新50

Disturbed mitochondrial dynamics in CD8+ TIL reinforce epigenetic programming linked with T cell exhaustion

免疫代谢

T细胞耗竭

The metabolic challenges present in tumors attenuate the metabolic fitness and anti-tumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic

NIAID Data Ecosystem60

scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

肿瘤免疫

T细胞耗竭

CD8+ T cell-mediated immune response plays a pivotal role in controlling tumor growth.However, within the tumor microenvironment (TME), prolonged antigen exposure, as well as immunosuppressive factors

NIAID Data Ecosystem60

Lymphopenia-induced T cell exhaustion in STING gain-of-function mouse model

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