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The dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

NIAID Data Ecosystem2026-03-14 收录

母细胞瘤靶向治疗

合成致死相互作用

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE161902 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2022-11-02

母细胞瘤靶向治疗

ALK信号通路

ALK mutations occur in 10% of primary neuroblastoma and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype with

NIAID Data Ecosystem90

HDACi and PLK1i synergize in MYC-amplified MB. HDACi and PLK1i synergize in MYC-amplified MB

母细胞瘤靶向治疗

药物协同作用

We and others have demonstrated that MYC-amplified medulloblastoma (MB) cells are susceptible towards treatment with class I histone deacetylase inhibitors (HDACi). However, single drug treatment with

NIAID Data Ecosystem70

Attenuating the emergence of anti-fungal drug resistance by harnessing synthetic lethal interactions in a model organism

抗菌药耐药性

合成致死相互作用

Drug resistance is a rapidly emerging concern, thus prompting the development of novel therapeutics or combinatorial therapy. Currently, combinatorial therapy targets are based on knowledge of drug mo

NIAID Data Ecosystem40

AC-265347 inhibits neuroblastoma tumor growth by induction of differentiation without causing hypocalcemia. AC-265347 inhibits neuroblastoma tumor growth by induction of differentiation without causing hypocalcemia

母细胞瘤靶向治疗

药物诱导分化

Neuroblastoma is the most common extracranial solid childhood tumor with clinical manifestations ranging from benign tumors that spontaneously regress to highly aggressive metastatic disease. Unfortun

NIAID Data Ecosystem80

Targeting transcription-replication conflicts is an effective therapeutic principle for MYCN-driven neuroblastoma [ChIPseq_IMR5_RNAseqH1]

母细胞瘤靶向治疗

转录复制冲突

Targeting the function of MYC proteins for therapy is a major challenge in tumor biology. MYC proteins are transcription factors that can globally release RNA polymerase II (RNAPII) from core promoter

NIAID Data Ecosystem50

The dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

资源简介：

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