cervical cancer SNP .xlsx

This
case-control group includes 488 cases of cervical cancer, 684 cases of cervical
precancerous lesions, and 510 healthy females. Multiplex polymerase
chain reaction (PCR) combined with next-generation sequencing method
was used for determination of gene polymorphisms (rs5498, rs3093030 and
rs281432). In our study, we divide cervical cancer into two subgroups: cervical
squamous cell carcinoma (CSCC) group and cervical adenocarcinoma (CAC) group.
We analyzed alleles and genotypes of all research subjects, and adjusted the
age using binary logistic regression analysis. In addition, we also analyzed
the distribution of haplotypes of the three SNPs in cervical cancer and
cervical precancerous lesions. We found that rs3093030 can reduce the risk of
cervical cancer, and rs5498 has a protective effect on the susceptibility of
CAC. In addition, the frequency of haplotype "CTG" was significantly
lower in the CAC group than in the controls. In conclusion, the study suggested
that ICAM-1 gene polymorphisms may have a potential role in the
pathogenesis of cervical cancer in the northern Chinese han population.