Although higher-order genome organization is tissue-specific, its functional relevance and mechanistic basis are poorly understood. Here we analyzed the dynamics of chromatin interactions for lineage

NIAID Data Ecosystem60

Analysis of epigenetic modification in C2C12 cells expressed H3.3-GFP at undifferentiated state

组蛋白变体定位

细胞分化表观遗传学

This project was analyzed to incorporation of H3.3 fusedC-terminal tagging GFP into chromatin in C2C12 cells.

NIAID Data Ecosystem60

Profiling of H3K9cr and H3K9ac in the P19 embryonal carcinoma cells

组蛋白修饰

细胞分化表观遗传学

To gain a deeper insight into dynamic changes of H3K9cr and H3K9ac during cell fate commitment, ChIP-seq was performed to analyze the genome-wide changes of H3K9cr and H3K9ac during neuroectodermal di

NIAID Data Ecosystem60

CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells [RNA-Seq]. CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells [RNA-Seq]

细胞分化表观遗传学

染色体空间组织

CD8+ T cells provide protection from infection and tumor growth, and many current immunotherapies target molecules that enhance CD8+ T cell function and differentiation. The transcriptional programs o

NIAID Data Ecosystem60

HDAC3 modulates enhancer activity to regulate terminal B cell differentiation

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