Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor

HCC has a poor response to therapy and a bad prognosis with chronic inflammation be the most common etiologies for HCC progression. Here we report a redox-dependent regulation mechanism of PIR protein nuclear shuttling, leading to liver inflammation and HCC progression. Primary Hepatocytes of Tg and Wt mice were isolated and cultured for 24 hours before subjected to RNA extraction.