Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits

Identification of new hits is one
of the biggest challenges in
drug discovery. Creating a library of well-characterized drug-like
compounds is a key step in this process. Our group has developed an
in-house chemical library called the Medicinal and Biological Chemistry
(MBC) library. This collection has been successfully used to start
several medicinal chemistry programs and developed in an accumulation
of more than 30 years of experience in drug design and discovery of
new drugs for unmet diseases. It contains over 1000 compounds, mainly
heterocyclic scaffolds. In this work, analysis of drug-like properties
and comparative study with well-known libraries by using different
computer software are presented here.