Liver DNAge of control and 17alpha-estradiol treated <i>APOE3 </i>and <i>APOE4 </i>mice

Beginning at age 10 months, male <i>APOE3</i> or <i>APOE4</i> mice were treated for 20 weeks with 17αE2 or vehicle then compared for indices of aging phenotypes body-wide. At the end of the 20 weeks, liver was snap frozen and sent to Zymo for their DNAge service.本研究于小鼠10月龄时启动，对雄性载脂蛋白E3（APOE3）或载脂蛋白E4（APOE4）小鼠分别采用17αE2与赋形剂进行为期20周的干预，随后对比分析两组小鼠的全身衰老表型相关指标。干预周期结束后，将肝脏组织液氮速冻并寄送Zymo公司，由其提供DNAge检测服务。

搜集汇总

背景与挑战

背景概述

该数据集记录了APOE3和APOE4基因型雄性小鼠在17α-雌二醇或对照处理20周后，肝脏DNA甲基化年龄（DNAge）的测量结果。研究旨在通过DNAge服务评估激素处理对衰老表型的影响，属于基因组学领域，数据以Excel文件形式提供，适用于衰老和表观遗传学分析。