PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

At the early endosome membrane, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) (Kraq et al. 2010, Arcaro et al. 2000) phosphorylates phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).

在早期内体膜上，含磷脂酰肌醇-4,5-二磷酸3-激酶C2结构域亚基α（PIK3C2A，Kraq等，2010年，Arcaro等，2000年）将磷脂酰肌醇-4,5-二磷酸（PI4P）磷酸化为磷脂酰肌醇-3,4-二磷酸（PI(3,4)P2）。