Projection of methylation test performance (scored as test-positive if at least 2 of 5 markers were methylated) in hrHPV positive women ≥30 years of age originated from a screening population [20].

sensitivity = Σ (pd*md)/Σ pd specificity = Σ (pn*(1-mn))/Σ pn.
p - proportion of women in the target population, m - proportion of methylation-positive women per group, d - group indices diseased, n - group indices non-diseased, NPV - negative predictive value, PPV - positive predictive value, prev – prevalence.