Supplementary materials: Estimating the risk of thrombotic events in people with congenital hemophilia A using US claims data

These are peer-reviewed supplementary tables for the article 'Estimating the risk of thrombotic events in people with congenital hemophilia A using US claims data' published in the Journal of Comparative Effectiveness Research.Supplemental Table 1A. ICD-9-CM and ICD-10-CM codes used to identify myocardial infarction.Supplemental Table 1B. ICD-9-CM and ICD-10-CM codes used to identify pulmonary embolism.Supplemental Table 1C. ICD-9-CM and ICD-10-CM codes used to identify ischemic stroke.Supplemental Table 1D. ICD-9-CM and ICD-10-CM codes used to identify deep vein thrombosis.Supplemental Table 1E. ICD-9-CM and ICD-10-CM codes used to identify device-related thrombosis.Supplemental Table 2A. ICD-9-CM and ICD-10-CM codes to identify HIV.Supplemental Table 2B. ICD-9-CM and ICD-10-CM codes to identify hepatitis C.Supplemental Table 3. Adjusted IRR (95% CI) by age group.Summary: Aim: Compare thrombotic risk in people with congenital hemophilia A (PwcHA) to the general non-hemophilia A (HA) population. Patients & methods: US claims databases were analyzed to identify PwcHA. Incidence rates of myocardial infarction, pulmonary embolism, ischemic stroke, deep vein thrombosis and device-related thrombosis were compared with a matched cohort without HA. Results: Over 3490 PwcHA were identified and 16,380 individuals matched. PwcHA had a similar incidence of myocardial infarction and pulmonary embolism compared with the non-HA population, but a slightly higher incidence of ischemic stroke and deep vein thrombosis. The incidence of device-related thrombosis was significantly higher in PwcHA. Conclusion: This analysis suggests that PwcHA are not protected against thrombosis, and provides context to evaluate thrombotic risk of HA treatments.

本数据集为发表于《比较疗效研究杂志》上的文章《利用美国索赔数据评估先天性血友病A患者血栓事件风险》的同行评审补充表格。补充表1A：用于识别心肌梗死的ICD-9-CM和ICD-10-CM编码。补充表1B：用于识别肺栓塞的ICD-9-CM和ICD-10-CM编码。补充表1C：用于识别缺血性卒中的ICD-9-CM和ICD-10-CM编码。补充表1D：用于识别深静脉血栓形成的ICD-9-CM和ICD-10-CM编码。补充表1E：用于识别设备相关血栓形成的ICD-9-CM和ICD-10-CM编码。补充表2A：用于识别HIV的ICD-9-CM和ICD-10-CM编码。补充表2B：用于识别丙型肝炎的ICD-9-CM和ICD-10-CM编码。补充表3：按年龄组调整后的IRR（95% CI）。摘要：目的：比较先天性血友病A患者（PwcHA）与一般非血友病A（HA）人群的血栓风险。研究方法：分析美国索赔数据库以识别PwcHA。比较心肌梗死、肺栓塞、缺血性卒中、深静脉血栓形成和设备相关血栓形成的发病率，并与无HA的匹配队列进行比较。结果：共识别3490名PwcHA患者和16,380名匹配个体。与无HA人群相比，PwcHA的心肌梗死和肺栓塞发病率相似，但缺血性卒中和深静脉血栓形成的发病率略高。设备相关血栓形成的发病率在PwcHA中显著更高。结论：本分析表明，PwcHA并未得到血栓形成的保护，并为评估HA治疗的血栓风险提供了背景信息。