Human PRMT5 in complex with AZ compound 1
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Human PRMT5 in complex with AZ compound 1 Descriptor: (1~{S})-2-[(2-carbamimidamido-1,3-thiazol-5-yl)methyl]-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-1~{H}-isoindole-1-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ... Authors: Debreczeni, J. Deposit date: 2024-04-09 Release date: 2024-08-14 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. J.Med.Chem., 67, 2024
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2024-04-09
