Tri-complex of Compound 1, KRAS G13C, and CypA

Tri-complex of Compound 1, KRAS G13C, and CypA Descriptor: (3R)-N-[(2S)-1-{[(1M,8R,10R,14S,21M)-22-ethyl-4-hydroxy-21-{2-[(1R)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]amino}-3-methyl-1-oxobutan-2-yl]-N-methyl-1-propanoylpyrrolidine-3-carboxamide (non-preferred name), Isoform 2B of GTPase KRas, MAGNESIUM ION, ... Authors: Read, B, Tomlinson, A.C.A, Knox, J.E, Yano, J.K. Deposit date: 2026-06-23 Release date: 2026-07-01 Last modified: 2026-07-15 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Selective Inhibition of KRASG13C Reveals an Increased Dependence on Wild-Type RAS Isoforms in Codon 13 RAS-Mutant Cancers. Cancer Discov, 2026