BackgroundNonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs).

NIAID Data Ecosystem20

Genome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations [CNV]

NMD途径调控

临床遗传学

Nonsense-mediated mRNA decay (NMD) surveillance pathways are best known to be involved in the degradation of mRNA with premature termination codons (PTCs). More recent studies demonstrate that the rol

NIAID Data Ecosystem30

In vitro and in vivo consequences of inflammatory regulation of Nonsense-Mediated RNA decay (NMD) pathway for pancreatic beta-cell function and viability

NMD途径调控

胰腺β细胞功能与存活

Ghiasi SM, et al., 2023: Aims/Hypothesis. Proinflammatory cytokines are implicated in pancreatic beta-cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and

NIAID Data Ecosystem30

siRNA profiling of human HeLa cells response to UPF1 depletion

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