Hedgehog ligand biogenesis

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>本事件系通过计算推理，源自于另一物种所展示的事件。推理过程基于PANTHER的同源性映射。简而言之，对于所有参与物理实体（包括输入、输出和催化剂）均存在同源或旁系同源映射的反应（对于复合体而言，至少75%的组分必须具备映射），均推断至另一物种。此外，对于这些事件，还推断出高级别事件，以便于更便捷的导航。<p>关于Reactome中事件推理的更多细节和注意事项，请参阅<a href='/electronic_inference_compara.html' target = 'NEW'>此链接</a>。有关PANTHER的详细信息，请参阅<a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>。

搜集汇总

背景与挑战

背景概述

该数据集总结了褐家鼠中刺猬配体生物发生的过程，这是一个通过计算从人类事件推断而来的信号通路事件。它详细描述了哺乳动物刺猬配体（如Sonic Hedgehog）的生成、修饰（包括胆固醇和棕榈酸化）以及分泌机制，这些过程对细胞间信号传导和发育调控至关重要。