Compounds that enhance the HMGB1-induced TNFα production of RAW264.7 cells.

Compounds augmenting the HMGB1-induced TNFα production by 2 standard deviation values are listed are listed in order of potency, according to their enhancing effect on TNFαα secretion. The source library of the compounds, their known biological activity and the respective viability values are shown. Viability was measured by the MTT assay. (Abbreviations: PKC: protein kinase C, HIV: human immunodeficiency virus, PDGF: platelet-derived growth factor, HMG-CoA: 3-hydroxy-3-methylglutaryl-coenzyme A, TrkA: TRK1-transforming tyrosine kinase protein).