Leukemia inhibitory factor regulates timing of oligodendrocyte development and myelination in postnatal optic nerve. Mus musculus

Oligodendrocyte precursor cells from postnatal day 10 optic nerve remained in a developmentally immature state in LIF-/- mice. Partial recovery of myelin genes is seen in LIF-/- mice by postnatal day 14 in the optic nerve. Very little difference in myelin genes in the optic nerve is seen by postnatal day 35 (adult). Overall design: Optic nerves from male mice postnatal day 10, day 14 and day 35 (adult)