Thematic collection: CHECK (Cohort Hip & Cohort Knee)

The Cohort Hip & Cohort Knee (CHECK) is a population-based observational multicenter cohort study of 1002 individuals with early symptomatic osteoarthritis (OA) of knee and/or hip in the Netherlands. The participants were followed for 10 years. The study evaluated clinical, radiographic and biochemical variables in order to establish the course, prognosis and underlying mechanisms of early symptomatic osteoarthritis. The Dutch Artritis Foundation initiated and funded this inception cohort. The data are stored in four separate datasets. See the overview below. See ‘Relations’ for a direct link to each dataset. - CHECK (Cohort Hip & Cohort Knee) data of baseline (T0): This dataset covers the data collection of baseline (T0) without the variable 'Subject identification number'. Also X-rays of hips and knees of baseline are available. More information on the variables can be found in the documentation. - CHECK (Cohort Hip & Cohort Knee) data of baseline to 5 years follow-up: This dataset covers the data collection from baseline to 5 years follow-up: T0, T1, T2, T3, T4 and T5. All data files include the variable 'Subject identification number’. Also X-rays of baseline, 2 and 5 year follow-up visits are available. - CHECK (Cohort Hip & Cohort Knee) data of baseline and 6 to 8 years follow-up: This dataset covers the data collection of baseline and 6 to 8 years follow-up: T0, T6, T7 and T8. All data files include the variable 'Subject identification number'. Also X-rays of hips, knees, hands and spine of T8 are available. The X-ray data are not included in the dataset, they are stored outside of EASY. More information on the variables can be found in the documentation. - CHECK (Cohort Hip & Cohort Knee) data of baseline and 9- 10 years follow-up This dataset covers the data collection of baseline and 9-10 years follow-up: T9 and T10 All data files include the variable 'Subject identification number.’ Also X-rays of hips and knees of baseline and 10 year follow-up visit are available. The X-ray data are not included in the dataset, they are stored outside of EASY. More information on the variables can be found in the documentation.. The first dataset is directly available for registered users. The other datasets are available when permission has been granted by CHECK. You can send in a permission request for each dataset via EASY via the tab ’Data files’ after logging in. Please note: the X-ray data are not included in the datasets, they are stored outside of EASY. Please consult the X-ray_data_request.pdf file to get more information on how to obtain this data.

髋部与膝部队列（CHECK，Cohort Hip & Cohort Knee）是一项基于人群的多中心观察性队列研究，在荷兰纳入1002名早期症状性膝部和/或髋部骨关节炎（osteoarthritis, OA）患者，随访时长为10年。本研究通过评估临床、影像学及生化变量，旨在明确早期症状性骨关节炎的病程、预后及潜在发病机制。该起始队列由荷兰关节炎基金会发起并资助。

研究数据分为四个独立数据集，详情如下，各数据集的直接链接详见「关联数据」栏目。
- CHECK基线（T0）数据集：该数据集包含基线（T0）阶段的全部采集数据，但不含「受试者识别号（Subject identification number）」变量。此外还可获取基线阶段的髋部与膝部X线影像数据。变量详情请查阅相关文档。
- CHECK基线至5年随访数据集：该数据集涵盖基线至5年随访阶段的所有采集数据，对应时间点为T0、T1、T2、T3、T4及T5。所有数据文件均包含「受试者识别号」变量。此外还可获取基线、2年及5年随访访视时的髋部与膝部X线影像数据。
- CHECK基线及6至8年随访数据集：该数据集涵盖基线与6至8年随访阶段的采集数据，对应时间点为T0、T6、T7及T8。所有数据文件均包含「受试者识别号」变量。此外还可获取T8访视时的髋部、膝部、手部及脊柱X线影像数据。本数据集未包含X线影像数据，相关影像数据存储于EASY系统之外。变量详情请查阅相关文档。
- CHECK基线及9至10年随访数据集：该数据集涵盖基线与9至10年随访阶段的采集数据，对应时间点为T9及T10。所有数据文件均包含「受试者识别号」变量。此外还可获取基线及10年随访访视时的髋部与膝部X线影像数据。本数据集未包含X线影像数据，相关影像数据存储于EASY系统之外。变量详情请查阅相关文档。

首个数据集对已注册用户直接开放。其余数据集需经CHECK研究团队授权后方可获取。登录EASY系统后，可通过「数据文件」标签页提交各数据集的权限申请。

请注意：本数据集未包含X线影像数据，相关影像数据存储于EASY系统之外。如需获取X线影像数据的详细流程，请查阅X-ray_data_request.pdf文件。