Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance chemotherapy resistance in AML cells through a TGF-β-p38-ALDH2 pathway
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=bd36386622dfbffb48f04e0f2b55a783
下载链接
链接失效反馈官方服务：
资源简介：
Our study aims to examine the interaction between AML cells and other cells in the tumor microenvironment, specifically bone marrow derived mesenchymal stromal cells. To delineate the specific genes/pathways involved in this interaction, we have co-cultured AML cell lines alone or with bone marrow derived mesenchymal stromal cells for 3 days, extracted total RNA from AML cells and analyzed the samples by RNA-seq. We identified the genes that are differentially expressed in co-cultured AML cells compared to AML cells alone. We found that TGF-β1 associated gene signature is activated in AML cells in the presence of BM-MSCs compared to AML cells alone.
提供机构：
MD Anderson Cancer Center
创建时间：
2022-02-20
