MicroRNA array expression during normal urinary bladder wound healing. MicroRNA array expression during normal urinary bladder wound healing

Urinary bladder wound healing is today pooorly chracterized. MicroRNAs are small non-coding RNA molecules with regulatory functions. In this study we aimed at identifying microRNAs expressed during bladder wound healing. We performed Affymetrix microRNA profiling of the rodent urinary bladder during healing of a surgically created wound. Overall design: Rat urinary bladder were collected at 0 hours ( control non wounded animals), 2 days and 8 days post insicional wound and sutures, 4 animals per time point were incliuded. The Affymetrix microRNA GeneChip Array plates (Affymetrix, Thermo Fisher) were used in this study according to the manufacturer’s instructions at the core facility for Bioinformatics and Expression Analysis (BEA, Karolinska Institutet, Stockholm, Sweden)